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      PDGFRα (5D1) Mouse mAb
      EM1336
      規格: 價格:
      50 μl ¥1280.00
      100 μl ¥1980.00

      Overview

      Product name: PDGFRα (5D1) Mouse mAb
      Reactivity: Human, Mouse, Rat
      Alternative Names: N/A
      Source: Mouse
      Applications : IHC
      Species: Human
      Recommended dilutions: IHC 1:100-200
      Immunogen: Synthetic Peptide
      Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid?repeated?freeze-thaw?cycles.
      Clonality: Monoclonal
      Isotype: IgG1
      Concentration: 1mg/ml
      Observed band: 180kDa
      GeneID(Human): 5156
      Cellular localization: Membrane
      Background: Platelet derived growth factor (PDGF) family proteins exist as several disulphide-bonded, dimeric isoforms (PDGF AA, PDGF AB, PDGF BB, PDGF CC, and PDGF DD) that bind in a specific pattern to two closely related receptor tyrosine kinases, PDGF receptor α (PDGFRα) and PDGF receptor β (PDGFRβ). PDGFRα and PDGFRβ can each form heterodimers with EGFR, which is also activated by PDGF. Various cells differ in the total number of receptors present and in the receptor subunit composition, which may account for responsive differences among cell types to PDGF binding. Ligand binding induces receptor dimerization and autophosphorylation, followed by binding and activation of cytoplasmic SH2 domain-containing signal transduction molecules, such as GRB2, Src, GAP, PI3 kinase, PLCγ, and NCK. A number of different signaling pathways are initiated by activated PDGF receptors and lead to control of cell growth, actin reorganization, migration, and differentiation.
      国产69精品久久久久久妇女迅雷