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    CK16 Mouse mAb
    EM1056
    規格: 價格:
    50 μl ¥1280.00
    100 μl ¥1980.00

    Overview

    Product name: CK16 Mouse mAb
    Reactivity: Human, Rat, Mouse
    Alternative Names: Cytokeratin 16, K16, K1CP, keratin 16, KRT16, KRT16A, NEPPK
    Source: Mouse
    Applications : IHC
    Species reactivity: Human, Rat, Mouse
    Species: Human
    Recommended dilutions: IHC 1:200
    Immunogen: Synthetic Peptide
    Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid?repeated?freeze-thaw?cycles.
    Clonality: Monoclonal
    Isotype: IgG1
    Concentration: 1mg/ml
    Observed band: 51kDa
    GeneID(Human): 3868
    Human Swiss-Prot No: P08779
    Cellular localization: Intermediate filament
    Background: Keratin 16 is expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation-related keratins). Keratin 16 is absent in normal breast tissue and in noninvasive breast carcinomas. Only 10% of the invasive breast carcinomas show diffuse or focal positivity. Reportedly, a relatively high concordance was found between the carcinomas immunostaining with the basal cell and the hyperproliferation-related keratins, but not between these markers and the proliferation marker Ki-67. This supports the conclusion that basal cells in breast cancer may show extensive proliferation, and that absence of Ki-67 staining does not mean that (tumor) cells are not proliferating.
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