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    CD68 Mouse mAb
    EM1050
    規格: 價格:
    50 μl ¥1280.00
    100 μl ¥1980.00

    Overview

    Product name: CD68 Mouse mAb
    Human Swiss-Prot No.: P34810
    Reactivity: Human, Rat, Mouse
    Alternative Names: CD68 molecule, GP110, Macrosialin, SCARD1
    Source: Mouse
    Applications : IHC
    Species reactivity: Human, Rat, Mouse
    Species: Human
    Recommended dilutions: IHC 1:200
    Immunogen: Synthetic Peptide
    Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid?repeated?freeze-thaw?cycles.
    Clonality: Monoclonal
    Isotype: IgG1
    Concentration: 1mg/ml
    Observed band: 37kDa
    GeneID(Human): 968
    Cellular localization: Cell membrane and Endosome membrane. Lysosome membrane
    Background: The CD68 antigen is a 37kD transmembrane protein that is post-translationally glycosylated to give a protein of 87-115kD. CD68 is specifically expressed by tissue macrophages, Langerhans cells and at low levels by dendritic cells. It could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin bearing substrates or other cells.
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