||DCC Rabbit pAb
||DCC; IGDCC1; Netrin receptor DCC; Colorectal cancer suppressor; Immunoglobulin superfamily DCC subclass member 1; Tumor suppressor protein DCC
||WB, IF, ELISA
||Synthesized peptide derived from the Internal region of human DCC. at AA rangle； 410-490
||PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Store at -20°C. Avoid?repeated?freeze-thaw?cycles.
||DCC encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein DCC netrin 1 receptor localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.