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      DCC Rabbit pAb
      ES4972
      規格: 價格:
      50 μl ¥1280.00
      100 μl ¥1980.00

      Overview

      Product name: DCC Rabbit pAb
      Reactivity: Human,Mouse,Rat
      Alternative Names: DCC; IGDCC1; Netrin receptor DCC; Colorectal cancer suppressor; Immunoglobulin superfamily DCC subclass member 1; Tumor suppressor protein DCC
      Source: Rabbit
      Applications: WB, IF, ELISA
      Immunogen: Synthesized peptide derived from the Internal region of human DCC. at AA rangle; 410-490
      Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid?repeated?freeze-thaw?cycles.
      Clonality: Polyclonal
      Concentration: 1mg/ml
      Observed band: 160kDa
      GeneID(Human): 1630
      Background: DCC encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein DCC netrin 1 receptor localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
      国产69精品久久久久久妇女迅雷